Bastian Zirpel


Production of tetrahydrocannabinolic acid synthase (THCA synthase) using yeasts Pichia pastoris and Saccharomyces cerevisiae and establishment of a two-phase-system


Area: expression
Project Start: 1.06.2013
Supervisor(s): Prof. Dr. Oliver Kayser, Dr. Armin Quendtmeier
University: Dortmund


Project overview

The THCA synthase is the enzyme catalyzing the last step of the THCA biosynthesis in the plant Cannabis sativa. In this project, the THCA synthase is recombinantly expressed in yeasts for purification and subsequent biochemical and functional characterizations. In future, the potential of yeasts for THCA production shall be investigated.


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