Marcello Siena


Using hyoscyamine-6ß-hydroxylase as biocatalyst for improved conversion of hyoscylamine to scopolamine


Area: biocatalysis
Project Start: 1.10.2010
Supervisor(s): Prof. Dr. Oliver Kayser, Prof. Dr. Rolf Wichmann
University: Dortmund


Scopolamine is an important precursor in pharmaceutical industry. The natural product is isolated from Duboisia plant in a complex way. In the remaining biomass the structurally related hyoscyamine is retained. Here we analyse and develop a biotechnological process to transform hyoscyamine to scopolamine to increase the yield by designing H6H for non-aqueous biocatalysis.


Project description
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Macello´s CV
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Marcello´s latest poster, April 2011
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