Dr. Dörte Rother (née Gocke)

University

Duesseldorf

department: FZ Juelich, Institute of Bio- and Geosciences: Biotechnology (IBG-1)

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University of Duesseldorf, campus FZ Juelich

Institute of Bio- and Geosciences: Biotechnology (IBG-1), Systems Biotechnology, Biocatalysis and Biosensors Group, Biocatalysis Group

Research interests

The biocatalysis group aims to optimise enzymatic reactions. Enzyme optimisation by site-directed mutagenesis or directed evolution is carried out to change substrate range, stability, activity and enantioselectivity. To analyse the technical potential of new enzymes, different bioreactors in batch and continuous mode are tested. Research in this area of reaction engineering also covers multi-enzyme reactions.

Enzymes with technical potential such as oxidoreductases (e.g. alcohol dehydrogenases, enoate reductases), lyases for C-C-bond formation (e.g. thiamin diphosphate dependent enzymes, hydroxynitrile lyases) and amino acid racemases are currently being tested and optimised. The enzymes are used as isolated biocatalysts as well as whole-cell systems.

To find out more, visit the website of the Biocatalysis Group.

Students (co-)supervised

Torsten Sehl