Torsten Sehl

Project

Identification and characterisation of enzymes for the stereo-selective two-step enzymatic synthesis of chiral amino alcohols

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Torsten was a fellow of the CLIB-Graduate Cluster Industrial Biotechnology and successfully defended his thesis. He is now a postdoctoral fellow at IGB-1, FZ Jülich.

Publications

Sehl T, Simon R, Hailes HC, Ward JM, Schell U, Pohl M, Rother D (2012) TTC-based screening assay for ?-transaminases: a rapid method to detect reduction of 2-hydroxy ketones. J Biotechnol; http://dx.doi.org/10.1016/j.jbiotec...

Sehl T, Hailes HC, Ward JM, Wardenga R, v. Lieres E, Offermann H, Westphal R, Pohl M, Rother D (2013) Two Steps in One Pot: Enzyme Cascade for the Synthesis of Nor(pseudo)ephedrine from Inexpensive Starting Materials. Angew. Chem. Int. Ed. 52: 6772-6775.

Sehl T, Hailes HC, Ward JM, Wardenga R, v. Lieres E, Offermann H, Westphal R, Pohl M, Rother D (2013) Zwei Schritte in einem Reaktionsgefäß: Enzymkaskaden zur selektiven Synthese von Nor(pseudo)ephedrin aus kostengünstigen Ausgangsmaterialien. Angew. Chem. 125: 6904-6908.

Rother D, Pohl M, Sehl T (2013) 2-Schritt Synthese zur Herstellung von (1S,2S)-Norpseudoephedrin (Cathine) durch Kopplung einer (S)-selektiven Transaminase und einer (S)-selektiven Alkoholdehydrogenase. Deutsche Patentanmeldung: 10 2013 009 145.4

Rother D, Pohl M, Sehl T, Gómez Baraibar Á (2013) 2-Schritt Synthese zur Herstellung von (1S,2S)-Norpseudoephedrin (Cathine) durch Kopplung einer (S)-selektiven Lyase und einer (S)-selektiven Transaminase. Deutsche Patentanmeldung: 10 2013 009 631.6

Sehl T, Kulig J, Westphal R, Rother D (2014) Synthetic Enzyme Cascades for Valuable Diols and Amino Alcohols: Smart Composition and Optimization Strategies. Book chapter for ‘Industrial Biocatalysis’ Grunwald P., ed., Pan Stanford Publishing Pte. Ltd., Singapore.

Sehl T, Hailes HC, Ward JM, Menyes U, Pohl M, Rother D (2014). Efficient 2-step biocatalytic strategies for the synthesis of all nor (pseudo) ephedrine isomers. Green Chem. 16: 3341–3348.

Sehl T, Maugeri Z, Rother D (2015). Multi-step synthesis strategies towards 1, 2-amino alcohols with special emphasis on phenylpropanolamines. J. Mol. Catal. B: Enzym. http://dx.doi.org/10.1016/j.molcatb...

Documents


Torsten’s project
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Torsten´s latest poster April 2011
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Torsten´s CV
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