Patrick Schwientek

Project

Applied systems biology of two actinoplanes species A. utahensis and A. friulensis.

Info

Area: polyomics
Project Start: 15.01.2009
Supervisor(s): Prof. Dr. Alfred Pühler, Prof. Dr. Jens Stoye
University: Bielefeld

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Alumnus

Patrick was an associate student of the CLIB-Graduate Cluster from June 2009 until March 2012. He received his doctorate on 19 March 2012 and became our first alumnus.

After his dissertation, Dr. Patrick Schwientek worked at the DOE Joint Genome Institute in San Francisco, CA, USA as a postdoctoral fellow. He is now a bioinformatics scientist for Bayer CropScience.

Project overview

Actinoplanes sp. SE50/110 is the wild type producer of the α-glucosidase inhi-bitor acarbose, a potent drug used worldwide in the treatment of type-2 diabetes mellitus. As a prerequisite for future targeted genetic optimization of acarbose yields, we sequenced the complete genome sequence of the organism and conducted subsequent RNA-sequencing experiments in order to analyse its genomic and transcriptomic properties. Thereby, we established the first complete genome sequence of a member of the genus Actinoplanes.

Genomics and transcriptomics of Actinoplanes sp. SE50/110

Documents


Patrick’s project
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Partrick’s latest poster
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