Sarah Schatschneider

Project

Analysis and modelling of the central carbohydrte metabolism of Xanthomonas campestris pv. campestris

Info

Area: polyomics
Project Start: 1.07.2009
Supervisor(s): Prof. Dr. Karsten Niehaus, Prof. Dr. Alfred Pühler
University: Bielefeld

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Alumna

Sarah was an associate student of the CLIB-Graduate Cluster. She finished her dissertation in June 2013 and joined the School of Pharmacy at Nottingham University, UK as a research fellow for two years. She now works for a multinational chemical company in Germany.

Project overview

The aim of this project is to enhance the exopolysaccharide (xanthan) production of Xanthomonas campestris pv. campestris by obtaining a deeper understanding of the Xcc central metabolism, which is the source for the precursors essential for xanthan biosynthesis. Therefore, relevant metabolic pathways should be reconstructed and analysed by means of systems biology. The results of these analyses should be validated by analysing the metabolic flux and the effect of mutations affecting relevant pathways.

Analysis and modelling of the central carbohydrate metabolism of Xanthomonas campestris pv. campestris

Publications

Schatschneider S, Vorhölter FJ, Rückert C, Becker A, Eisenreich W, Pühler A, Niehaus K (2011). Genome-enabled determination of amino acid biosynthesis in Xanthomonas campestris pv. campestris and identification of biosynthetic pathways fo ralanine, glycine, and isoleucine by 13C-isotopologue profiling. Mol Genet Genomics 286(3-4):247-59.

Dynamic protein phosphorylation during the growth of Xanthomonas campestris pv. campestris B100 revealed by a gel-based proteomics approach. Musa Y. R., Bäsell K., Schatschneider S., Vorhölter F. J., Becher D., Niehaus K. J. Biotechnol 2013 20;167(2):111-22

Establishment, in silico analysis, and experimental verification of a large-scale metabolic network of the xanthan producing Xanthomonas campestris pv. campestris B100”. Schatschneider S., Persicke M., Watt S. A., Hublik G., Pühler A., Niehaus K., Vorhölter F. J. J Biotechnol. 2013 20:167(2):123-34

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