Robert Kulis-Horn


Genome based development of a histidine production strain on the basis of the amino acid producer Corynebacterium glutamicum


Area: polyomics
Project Start: 1.12.2009
Supervisor(s): Dr. Jörn Kalinowski, Prof. Dr. Alfred Pühler
University: Bielefeld


Robert successfully defended his thesis in July 2015 and received his doctorate degree from Bielefeld University.

Project overview

The production of L-histidine is of commercial interest, as this semi-essential amino acid is used as feed supplement, for instance in the aquaculture industry.

The aim of the project is the construction of a histidine production strain with well defined genomic mutations. Conclusions from genomic sequence information from histidine production strains created by random mutagenesis will help identifying targets for genetic engineering.


Histidine biosynthesis, its regulation and biotechnological application in Corynebacterium glutamicum. Kulis R, Persicke M, Kalinowski J (2014) Microbial Biotechnology 7(1): 5–25.


Robert’s project
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