Mari Jääskeläinen

Project

Using Corynebacterium glutamicum to produce industrial proteins from GC-rich DNA

Info

Area: polyomics
Project Start: 1.10.2011
Supervisor(s): Dr. Jörn Kalinowski, Prof. Dr. Volker Wendisch
University: Bielefeld

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Microbial Genomics and Biotechnology, CeBiTec, Bielefeld University

Project overview

Many industrially interesting proteins are from Actinobacterial species that are known to have GC-rich genomes. Genes with a high GC-content are usually not easy to express. C. glutamicum has a lot of qualities to be a good host to produce recombinant proteins from GC-rich DNA, but this feature has not yet been studied widely. In this study, we ask which factors affect the protein production in C. glutamicum and how these factors might be changed to maximize the amount of protein produced.

Using Corynebacterium glutamicum to produce industrial proteins from GC-rich DNA

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Mari’s project
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