Lars Freier


Hybrid mechanistic-empirical modeling of enzyme catalyzed processes


Area: biocatalysis
Project Start: 1.11.2013
Supervisor(s): Dr. Eric von Lieres, Prof. Dr. Wolfgang Wiechert
University: Duesseldorf


Project overview

Biotechnological processes are generally complex functions of several unknowns. Mechanistic models can hardly take all impact factors into account. Hence, we apply the Kriging approach to combine mechanistic models for describing major impact factors with empirical models for describing the remaining discrepancies between trend functions and measurements. This approach will be combined with different optimization algorithms for model-based data analysis and process design.


Lars’ project
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