Andreas Domröse


Functional expression of clustered genes encoding biosynthetic pathways


Area: expression
Project Start: 1.05.2013
Supervisor(s): Prof. Dr. Karl-Erich Jaeger, Dr. Thomas Drepper
University: Duesseldorf


Project overview

In order to gain access to high value compounds, whose biosynthetic pathways are encoded by clustered genes, we have developed the TREX (transfer and expression) system. TREX is a synthetic biology tool that enables the transfer, randomized genome integration and bidirectional expression of complex gene clusters in a broad range of bacterial hosts. Within this project, TREX will be applied to construct different Pseudomonas putida production strains for high level synthesis of prodigiosin.


Andreas’ project
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