Helena Barzantny

Project

Elucidation of fatty acid degradation pathways of C. jeikeium K411.

Info

Area: polyomics
Project Start: 1.11.2009
Supervisor(s): Prof. Dr. Karsten Niehaus, apl. Prof. Dr. Andreas Tauch
University: Bielefeld

More

Alumna

Helena was a student of the CLIB-GC from Nov 2009 until Jan 2013. She sucessfully defended her thesis on 31 January 2013. She is now a teamleader in applied genetics at an international life science company.

Project overview

Corynebacterium jeikeium K411 is a lipophilic resident of the human axilla. It is missing a gene coding for a fatty acid synthase and is therefore dependent on exogenous fatty acids. The degradation of lipid compounds in the axilla is mediated by corynebacterial enzymes and contributes to human body odour formation. The project investigates the transcriptional regulation of multiple β-oxidation genes to better understand these degradation processes in the human axilla and their contribution to human body odour.

Elucidation of fatty acid degradation pathways of C. jeikeium K411

Publications

Brune I, Barzantny H, Klötzel M, Jones J, James G, Tauch A (2010). Identification of McbR as transcription regulator of aecD and genes involved in methionine and cysteine biosynthesis in Corynebacterium jeikeium K411. J Biotechnol 151(1):22-9

Barzantny H, Schröder J, Strotmeier J, Fredrich E, Brune I, Tauch A The transcriptional regulatory network of Corynebacterium jeikeium K411 and its interaction with metabolic routes contributing to human body odor formation. J Biotechnol. 2012 Jun 15;159(3):235-48.

Barzantny H, Brune I, Tauch A (2012). Molecular basis of human body odour formation: insights deduced from corynebacterial genomes. Int J Cosmet Sci 34(1):2-11

Transcriptional control of lipid metabolism by the MarR–like regulator FamR and the global regulator GlxR in the lipophilic axilla isolate Corynebacterium jeikieum K411. Barzantny H., Guttmann S., Lässig C., Brune I., Tauch A. Microb Biotechnol. 2013; 6(2):118-30

Document


Helena’s project
PDF (52.7 kb)